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Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles

Author

Listed:
  • Cheryl L. Birmingham

    (Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Department of Molecular Genetics,)

  • Veronica Canadien

    (Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Natalia A. Kaniuk

    (Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada)

  • Benjamin E. Steinberg

    (Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada)

  • Darren E. Higgins

    (Harvard Medical School, Boston, Massachusetts 02115-6092, USA)

  • John H. Brumell

    (Cell Biology Program, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Department of Molecular Genetics,
    Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada)

Abstract

Listeriosis: trouble in store The bacterial pathogen Listeria monocytogenes is a common a cause of infection in immunocompromised individuals and in pregnancy. It multiplies rapidly in the cytosol of infected cells, but was recently found in intracellular vacuoles in a mouse model of the disease. A closer study of these vacuoles in mice during persistent listeriosis reveals them as sites of comparably slow bacterial replication which may promote bacterial survival in the face of the host immune response.

Suggested Citation

  • Cheryl L. Birmingham & Veronica Canadien & Natalia A. Kaniuk & Benjamin E. Steinberg & Darren E. Higgins & John H. Brumell, 2008. "Listeriolysin O allows Listeria monocytogenes replication in macrophage vacuoles," Nature, Nature, vol. 451(7176), pages 350-354, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7176:d:10.1038_nature06479
    DOI: 10.1038/nature06479
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