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Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

Author

Listed:
  • Wenqiang Yu

    (Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA)

  • David Gius

    (Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, 3B43, 9000 Rockville Pike, Bethesda, Maryland 20892, USA)

  • Patrick Onyango

    (Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA)

  • Kristi Muldoon-Jacobs

    (Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, 3B43, 9000 Rockville Pike, Bethesda, Maryland 20892, USA)

  • Judith Karp

    (Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 401 North Broadway, Baltimore, Maryland 21231, USA)

  • Andrew P. Feinberg

    (Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA)

  • Hengmi Cui

    (Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA)

Abstract

Widespread sense-antisense transcripts have been identified in mammalian cells. Many tumour suppressor genes have nearby antisense RNAs, and an antisense RNA to the cyclin-dependent kinase inhibitor p15 can silence the p15 gene by inducing heterochromatin formation.

Suggested Citation

  • Wenqiang Yu & David Gius & Patrick Onyango & Kristi Muldoon-Jacobs & Judith Karp & Andrew P. Feinberg & Hengmi Cui, 2008. "Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA," Nature, Nature, vol. 451(7175), pages 202-206, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7175:d:10.1038_nature06468
    DOI: 10.1038/nature06468
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