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Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

Author

Listed:
  • Shota Atsumi

    (Department of Chemical and Biomolecular Engineering,)

  • Taizo Hanai

    (Department of Chemical and Biomolecular Engineering,)

  • James C. Liao

    (Department of Chemical and Biomolecular Engineering,
    UCLA-DOE Insitute for Genomics and Proteomics, University of California, Los Angeles, 5531 Boelter Hall, 420 Westwood Plaza, Los Angeles, California 90095, USA)

Abstract

Aiming high in biofuels 'Higher' alcohols offer advantages over ethanol as biofuels thanks to their higher energy densities and lower hygroscopicities, and 'branched' alcohols have higher octane numbers than their straight-chain counterparts. But these other alcohols cannot be synthesized economically using native microorganisms. Now an Escherichia coli strain has been re-engineered to produce higher alcohols (including isobutanol, 1-butanol and 2-phenylethanol) from glucose, a renewable carbon source. The strategy involves diverting intermediates from the amino acid biosynthetic pathway to generate the desired alcohol and may facilitate large-scale production of biofuels by microbial fermentation.

Suggested Citation

  • Shota Atsumi & Taizo Hanai & James C. Liao, 2008. "Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels," Nature, Nature, vol. 451(7174), pages 86-89, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7174:d:10.1038_nature06450
    DOI: 10.1038/nature06450
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