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Trisomy represses ApcMin -mediated tumours in mouse models of Down’s syndrome

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  • Thomas E. Sussan

    (The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Present address: Department of Environmental Health Sciences, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA.)

  • Annan Yang

    (The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Fu Li

    (Ohio State University, Columbus, Ohio 43210, USA)

  • Michael C. Ostrowski

    (Ohio State University, Columbus, Ohio 43210, USA)

  • Roger H. Reeves

    (The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

Abstract

Down's syndrome cancers Some epidemiological studies have suggested that individuals with Down's syndrome (who carry three copies of chromosome 21, known as trisomy 21) show a reduced incidence of solid tumours. Other studies failed to confirm this. Experiments in the Ts65Dn mouse model of Down's syndrome, trisomic for about 100 genes, may have resolved these contradictory findings. They reveal that trisomy for a subset of mouse equivalents of chromosome 21 genes reduces the incidence of some intestinal tumours, yet the presence of one copy of the same genes increases the number of tumours. The dosage-dependent effect is attributed to the Ets2 transcription factor. So Ets2, known until now as an oncogene, is also a tumour repressor, and is a potential target for anticancer prophylaxis.

Suggested Citation

  • Thomas E. Sussan & Annan Yang & Fu Li & Michael C. Ostrowski & Roger H. Reeves, 2008. "Trisomy represses ApcMin -mediated tumours in mouse models of Down’s syndrome," Nature, Nature, vol. 451(7174), pages 73-75, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7174:d:10.1038_nature06446
    DOI: 10.1038/nature06446
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