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TRPC channel activation by extracellular thioredoxin

Author

Listed:
  • Shang-Zhong Xu

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,
    Present address: Postgraduate Medical Institute & Hull York Medical School, University of Hull, Cottingham Road, Hull HU6 7RX, UK.)

  • Piruthivi Sukumar

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Fanning Zeng

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Jing Li

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Amit Jairaman

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Anne English

    (Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital)

  • Jacqueline Naylor

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Coziana Ciurtin

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Yasser Majeed

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Carol J. Milligan

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Yahya M. Bahnasi

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Eman Al-Shawaf

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Karen E. Porter

    (School of Medicine, University of Leeds, Leeds LS2 9JT, UK)

  • Lin-Hua Jiang

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • Paul Emery

    (Academic Unit of Musculoskeletal Disease, Chapel Allerton Hospital)

  • Asipu Sivaprasadarao

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

  • David J. Beech

    (Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, and,)

Abstract

Reducing agents can activate different members of the transient receptor potential (TRP) superfamily of ion channels (TRPC1 and TRPC5) by breaking a disulphide bridge in the extracellular loop adjacent to the ion permation pore. A high concentration of the endogenous reducing agent, thioredoxin, is present in rheumatoid arthritis and may reduce secretion of matrix metalloproteinases by its inhibition of TRPC1 and TRPC5.

Suggested Citation

  • Shang-Zhong Xu & Piruthivi Sukumar & Fanning Zeng & Jing Li & Amit Jairaman & Anne English & Jacqueline Naylor & Coziana Ciurtin & Yasser Majeed & Carol J. Milligan & Yahya M. Bahnasi & Eman Al-Shawaf, 2008. "TRPC channel activation by extracellular thioredoxin," Nature, Nature, vol. 451(7174), pages 69-72, January.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7174:d:10.1038_nature06414
    DOI: 10.1038/nature06414
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