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High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons

Author

Listed:
  • Ede A. Rancz

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Taro Ishikawa

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Ian Duguid

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Paul Chadderton

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Séverine Mahon

    (University College London, Gower Street, London WC1E 6BT, UK)

  • Michael Häusser

    (University College London, Gower Street, London WC1E 6BT, UK)

Abstract

Sensitive synapses Synaptic boutons, the points of communication between nerve cells, are so tiny that it has been impossible to record their electrical activity without slicing the brain. In a technical tour de force, Rancz et al. provide the first intracellular recordings from presynaptic boutons in the intact mammalian brain. Their results contradict the prevailing views — derived from in vitro work — on how the cerebellum integrates sensory information to control movement, by revealing an unexpected sensitivity of single brain connections to stimuli from the environment.

Suggested Citation

  • Ede A. Rancz & Taro Ishikawa & Ian Duguid & Paul Chadderton & Séverine Mahon & Michael Häusser, 2007. "High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons," Nature, Nature, vol. 450(7173), pages 1245-1248, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7173:d:10.1038_nature05995
    DOI: 10.1038/nature05995
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