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The biological impact of mass-spectrometry-based proteomics

Author

Listed:
  • Benjamin F. Cravatt

    (The Scripps Research Institute
    The Skaggs Institute for Chemical Biology, The Scripps Research Institute)

  • Gabriel M. Simon

    (The Scripps Research Institute
    The Skaggs Institute for Chemical Biology, The Scripps Research Institute)

  • John R. Yates III

    (The Scripps Research Institute)

Abstract

In the past decade, there have been remarkable advances in proteomic technologies. Mass spectrometry has emerged as the preferred method for in-depth characterization of the protein components of biological systems. Using mass spectrometry, key insights into the composition, regulation and function of molecular complexes and pathways have been gained. From these studies, it is clear that mass-spectrometry-based proteomics is now a powerful 'hypothesis-generating engine' that, when combined with complementary molecular, cellular and pharmacological techniques, provides a framework for translating large data sets into an understanding of complex biological processes.

Suggested Citation

  • Benjamin F. Cravatt & Gabriel M. Simon & John R. Yates III, 2007. "The biological impact of mass-spectrometry-based proteomics," Nature, Nature, vol. 450(7172), pages 991-1000, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7172:d:10.1038_nature06525
    DOI: 10.1038/nature06525
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