IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v450y2007i7172d10.1038_nature06431.html
   My bibliography  Save this article

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

Author

Listed:
  • Adam G. W. Matthews

    (Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Alex J. Kuo

    (Stanford University, Stanford, California 94305, USA)

  • Santiago Ramón-Maiques

    (Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, Maryland 20892, USA)

  • Sunmi Han

    (Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Karen S. Champagne

    (University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA)

  • Dmitri Ivanov

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Mercedes Gallardo

    (Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Dylan Carney

    (Stanford University, Stanford, California 94305, USA)

  • Peggie Cheung

    (Stanford University, Stanford, California 94305, USA)

  • David N. Ciccone

    (Harvard Medical School, Boston, Massachusetts 02114, USA)

  • Kay L. Walter

    (Stanford University, Stanford, California 94305, USA)

  • Paul J. Utz

    (Stanford University School of Medicine, Stanford, California 94305, USA)

  • Yang Shi

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Tatiana G. Kutateladze

    (University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA)

  • Wei Yang

    (Laboratory of Molecular Biology, NIDDK, NIH, Bethesda, Maryland 20892, USA)

  • Or Gozani

    (Stanford University, Stanford, California 94305, USA)

  • Marjorie A. Oettinger

    (Harvard Medical School, Boston, Massachusetts 02114, USA)

Abstract

RAG2, a component of the V(D)J recombinase, has a plant homeodomain (PHD) domain which specifically recognizes histone H3 trimethylated at lysine 4 (H3K4me3). A crystal structure of the complex is presented, and the interaction between RAG2 and H3K4me3 shown to be important for V(D)J recombination in vivo.

Suggested Citation

  • Adam G. W. Matthews & Alex J. Kuo & Santiago Ramón-Maiques & Sunmi Han & Karen S. Champagne & Dmitri Ivanov & Mercedes Gallardo & Dylan Carney & Peggie Cheung & David N. Ciccone & Kay L. Walter & Paul, 2007. "RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination," Nature, Nature, vol. 450(7172), pages 1106-1110, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7172:d:10.1038_nature06431
    DOI: 10.1038/nature06431
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature06431
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature06431?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:450:y:2007:i:7172:d:10.1038_nature06431. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.