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Distinct physiological states of Plasmodium falciparum in malaria-infected patients

Author

Listed:
  • J. P. Daily

    (Department of Immunology and Infectious Disease,
    Brigham and Women’s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA)

  • D. Scanfeld

    (Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • N. Pochet

    (Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    FAS Center for Systems Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA)

  • K. Le Roch

    (900 University Avenue, University of California, Riverside, California 92521, USA)

  • D. Plouffe

    (Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA)

  • M. Kamal

    (Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • O. Sarr

    (Laboratory of Bacteriology and Virology,)

  • S. Mboup

    (Laboratory of Bacteriology and Virology,)

  • O. Ndir

    (Dantec Hospital, Cheikh Anta Diop University, Dakar, BP 5005, Senegal)

  • D. Wypij

    (Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA)

  • K. Levasseur

    (Department of Immunology and Infectious Disease,)

  • E. Thomas

    (Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • P. Tamayo

    (Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • C. Dong

    (Department of Immunology and Infectious Disease,)

  • Y. Zhou

    (Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA)

  • E. S. Lander

    (Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Massachusetts Institute of Technology, 31 Ames Street, Cambridge, Massachusetts 02139, USA
    The Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • D. Ndiaye

    (Dantec Hospital, Cheikh Anta Diop University, Dakar, BP 5005, Senegal)

  • D. Wirth

    (Department of Immunology and Infectious Disease,)

  • E. A. Winzeler

    (Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, California 92037, USA)

  • J. P. Mesirov

    (Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA)

  • A. Regev

    (Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Massachusetts Institute of Technology, 31 Ames Street, Cambridge, Massachusetts 02139, USA)

Abstract

Triple identity for malaria A major puzzle in understanding malaria is the wide range of clinical conditions seen in infected children — from mild flu-like symptoms to coma and death. A large-scale transcriptional analysis of malaria parasites isolated from human patients has uncovered a possible clue to this variation: Plasmodium falciparum exists in its human host in three different physiological states. These can be described as active growth, a response to starvation, and an environmental stress response. This finding has important implications both for treatment with current drugs and for future drug and vaccine development.

Suggested Citation

  • J. P. Daily & D. Scanfeld & N. Pochet & K. Le Roch & D. Plouffe & M. Kamal & O. Sarr & S. Mboup & O. Ndir & D. Wypij & K. Levasseur & E. Thomas & P. Tamayo & C. Dong & Y. Zhou & E. S. Lander & D. Ndia, 2007. "Distinct physiological states of Plasmodium falciparum in malaria-infected patients," Nature, Nature, vol. 450(7172), pages 1091-1095, December.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7172:d:10.1038_nature06311
    DOI: 10.1038/nature06311
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