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Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

Author

Listed:
  • Eric Dessaud

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Lin Lin Yang

    (University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Present address: Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.)

  • Katy Hill

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Barny Cox

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Fausto Ulloa

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Ana Ribeiro

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Anita Mynett

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

  • Bennett G. Novitch

    (University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Present address: Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA.)

  • James Briscoe

    (Developmental Neurobiology, National Institute for Medical Research Mill Hill)

Abstract

Understanding morphogen activity is one of the longest standing problems in developmental biology. Both the duration of exposure to the secreted morphogen Sonic hedgehog (Shh) and the concentration of Shh are important in determining the fate of cells in the neural tube and in the limb bud. This paper clarifies the relationship between time and concentration in Shh signalling during patterning of the neural tube.

Suggested Citation

  • Eric Dessaud & Lin Lin Yang & Katy Hill & Barny Cox & Fausto Ulloa & Ana Ribeiro & Anita Mynett & Bennett G. Novitch & James Briscoe, 2007. "Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism," Nature, Nature, vol. 450(7170), pages 717-720, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7170:d:10.1038_nature06347
    DOI: 10.1038/nature06347
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    Cited by:

    1. Chakraborty, Priya & Jolly, Mohit Kumar & Roy, Ushasi & Ghosh, Sayantari, 2023. "Spatio-temporal pattern formation due to host-circuit interplay in gene expression dynamics," Chaos, Solitons & Fractals, Elsevier, vol. 167(C).
    2. Wenxian Wang & Hyeyoung Cho & Jae W. Lee & Soo-Kyung Lee, 2022. "The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    3. Roman Vetter & Dagmar Iber, 2022. "Precision of morphogen gradients in neural tube development," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Seth Teague & Gillian Primavera & Bohan Chen & Zong-Yuan Liu & LiAng Yao & Emily Freeburne & Hina Khan & Kyoung Jo & Craig Johnson & Idse Heemskerk, 2024. "Time-integrated BMP signaling determines fate in a stem cell model for early human development," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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