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Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1

Author

Listed:
  • Coenraad Kuijl

    (and)

  • Nigel D. L. Savage

    (Leiden Medical University Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands)

  • Marije Marsman

    (and)

  • Adriaan W. Tuin

    (Leiden Institute of Chemistry)

  • Lennert Janssen

    (and)

  • David A. Egan

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Mirjam Ketema

    (and)

  • Rian van den Nieuwendijk

    (Leiden Institute of Chemistry)

  • Susan J. F. van den Eeden

    (Leiden Medical University Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands)

  • Annemieke Geluk

    (Leiden Medical University Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands)

  • Alex Poot

    (Leiden Institute of Chemistry)

  • Gijs van der Marel

    (Leiden Institute of Chemistry)

  • Roderick L. Beijersbergen

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands)

  • Hermen Overkleeft

    (Leiden Institute of Chemistry)

  • Tom H. M. Ottenhoff

    (Leiden Medical University Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands)

  • Jacques Neefjes

    (and)

Abstract

An alternative to antibiotics Conventional antibiotics work by inactivating important pathogen functions, and they are therefore susceptible to the development of antibiotic resistance. An alternative approach is to target host factors that support pathogen growth. A possible target for this approach has been identified using a novel RNA interference screen for kinases capable of inhibiting intracellular growth of Salmonella typhimurium and Mycobacterium tuberculosis. The key molecule is AKT1, a kinase previously known as PKB, and extensively studied because of its anti-apoptotic activity and involvement in uncontrolled cancers.

Suggested Citation

  • Coenraad Kuijl & Nigel D. L. Savage & Marije Marsman & Adriaan W. Tuin & Lennert Janssen & David A. Egan & Mirjam Ketema & Rian van den Nieuwendijk & Susan J. F. van den Eeden & Annemieke Geluk & Alex, 2007. "Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1," Nature, Nature, vol. 450(7170), pages 725-730, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7170:d:10.1038_nature06345
    DOI: 10.1038/nature06345
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