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The centromere geometry essential for keeping mitosis error free is controlled by spindle forces

Author

Listed:
  • Jadranka Lončarek

    (Wadsworth Center, Albany, Albany, New York 12201-0509, USA)

  • Olga Kisurina-Evgenieva

    (Wadsworth Center, Albany, Albany, New York 12201-0509, USA
    Present address: Department of Cytology, Biology Faculty, Moscow State University, Moscow 119991, Russia.)

  • Tatiana Vinogradova

    (Wadsworth Center, Albany, Albany, New York 12201-0509, USA)

  • Polla Hergert

    (Wadsworth Center, Albany, Albany, New York 12201-0509, USA)

  • Sabrina La Terra

    (Wadsworth Center, Albany, Albany, New York 12201-0509, USA
    State University of New York, Albany, New York 12222, USA)

  • Tarun M. Kapoor

    (Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, New York 10021, USA)

  • Alexey Khodjakov

    (Wadsworth Center, Albany, Albany, New York 12201-0509, USA
    State University of New York, Albany, New York 12222, USA
    Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, New York 10021, USA)

Abstract

This paper addresses the question of how centromere architecture affects spindle formation, and presents evidence supporting the claim that centromeres are malleable with respect to tangential forces. Once deformed, they remain in this position until they are straightened by external forces applied along microtubules.

Suggested Citation

  • Jadranka Lončarek & Olga Kisurina-Evgenieva & Tatiana Vinogradova & Polla Hergert & Sabrina La Terra & Tarun M. Kapoor & Alexey Khodjakov, 2007. "The centromere geometry essential for keeping mitosis error free is controlled by spindle forces," Nature, Nature, vol. 450(7170), pages 745-749, November.
  • Handle: RePEc:nat:nature:v:450:y:2007:i:7170:d:10.1038_nature06344
    DOI: 10.1038/nature06344
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