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Calcineurin sets the bandwidth for discrimination of signals during thymocyte development

Author

Listed:
  • Elena M. Gallo

    (Stanford University, Stanford, California 94305, USA
    Program in Immunology, Stanford University, Stanford University, Stanford, California 94305, USA)

  • Monte M. Winslow

    (Stanford University, Stanford, California 94305, USA
    Program in Immunology, Stanford University, Stanford University, Stanford, California 94305, USA
    Present addresses: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA (M.M.W., J.R.N.); Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2300 RC, The Netherlands (K.C.-B.).)

  • Kirsten Canté-Barrett

    (Stanford University, Stanford, California 94305, USA
    Program in Immunology, Stanford University, Stanford University, Stanford, California 94305, USA
    Present addresses: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA (M.M.W., J.R.N.); Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2300 RC, The Netherlands (K.C.-B.).)

  • Amy N. Radermacher

    (Stanford University, Stanford, California 94305, USA
    Program in Immunology, Stanford University, Stanford University, Stanford, California 94305, USA)

  • Lena Ho

    (Stanford University, Stanford, California 94305, USA
    Program in Immunology, Stanford University, Stanford University, Stanford, California 94305, USA)

  • Lisa McGinnis

    (Stanford University, Stanford, California 94305, USA
    Program in Immunology, Stanford University, Stanford University, Stanford, California 94305, USA)

  • Brian Iritani

    (School of Medicine, University of Washington, Seattle, Washington 98195, USA)

  • Joel R. Neilson

    (Stanford University, Stanford, California 94305, USA
    Stanford University, Stanford, California 94305, USA
    Present addresses: Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA (M.M.W., J.R.N.); Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden 2300 RC, The Netherlands (K.C.-B.).)

  • Gerald R. Crabtree

    (Stanford University, Stanford, California 94305, USA
    Program in Immunology, Stanford University, Stanford University, Stanford, California 94305, USA)

Abstract

Immature thymic T cells receive signals through the T cell receptor which determine whether they undergo positive or negative selection. Calcineurin/NFAT signalling in preselection thymocytes produces a temporal window with enhanced signalling sensitivity paving the way for positive selection.

Suggested Citation

  • Elena M. Gallo & Monte M. Winslow & Kirsten Canté-Barrett & Amy N. Radermacher & Lena Ho & Lisa McGinnis & Brian Iritani & Joel R. Neilson & Gerald R. Crabtree, 2007. "Calcineurin sets the bandwidth for discrimination of signals during thymocyte development," Nature, Nature, vol. 450(7170), pages 731-735, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7170:d:10.1038_nature06305
    DOI: 10.1038/nature06305
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