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BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

Author

Listed:
  • Daeho Park

    (Department of Cell Biology,
    Carter Immunology Center,)

  • Annie-Carole Tosello-Trampont

    (Carter Immunology Center,)

  • Michael R. Elliott

    (Carter Immunology Center,)

  • Mingjian Lu

    (Department of Microbiology,
    Present address: Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.)

  • Lisa B. Haney

    (Carter Immunology Center,)

  • Zhong Ma

    (Carter Immunology Center,)

  • Alexander L. Klibanov

    (Cardiovascular Division and,)

  • James W. Mandell

    (University of Virginia, Charlottesville, Virginia 22908, USA)

  • Kodi S. Ravichandran

    (Carter Immunology Center,
    Department of Microbiology,)

Abstract

Apoptosis on the menu During programmed cell death in multicellular organisms, a large number of cells are engulfed by macrophages, thus avoiding the release of noxious materials from the dying cells. These 'apoptotic' cells expose phosphatidylserine (PS) on their surface as an 'eat-me' signal. Miyanishi et al. show that the receptors Tim4 and Tim1 are implicated in phagocyte recognition of PS, while Park et al. show that the BAI1 protein is a receptor for PS in mammalian macrophages.

Suggested Citation

  • Daeho Park & Annie-Carole Tosello-Trampont & Michael R. Elliott & Mingjian Lu & Lisa B. Haney & Zhong Ma & Alexander L. Klibanov & James W. Mandell & Kodi S. Ravichandran, 2007. "BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module," Nature, Nature, vol. 450(7168), pages 430-434, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7168:d:10.1038_nature06329
    DOI: 10.1038/nature06329
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