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Molecular basis of RNA-dependent RNA polymerase II activity

Author

Listed:
  • Elisabeth Lehmann

    (Gene Center Munich and Center for integrated Protein Science (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany)

  • Florian Brueckner

    (Gene Center Munich and Center for integrated Protein Science (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany)

  • Patrick Cramer

    (Gene Center Munich and Center for integrated Protein Science (CiPSM), Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany)

Abstract

New tricks RNA polymerase II, the enzyme responsible for transcription, the first step in gene expression, was thought to use only DNA as a template. But it now emerges that RNA polymerase II can also produce complementary RNA products from an RNA template. This newly discovered activity of a central player in eukaryotic cells is probably involved in gene regulatory mechanisms that are based on small RNA molecules.

Suggested Citation

  • Elisabeth Lehmann & Florian Brueckner & Patrick Cramer, 2007. "Molecular basis of RNA-dependent RNA polymerase II activity," Nature, Nature, vol. 450(7168), pages 445-449, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7168:d:10.1038_nature06290
    DOI: 10.1038/nature06290
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