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Maternal nodal and zebrafish embryogenesis

Author

Listed:
  • James T. Bennett

    (Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine
    New York University School of Medicine)

  • Heather L. Stickney

    (Stanford University)

  • Wen-Yee Choi

    (Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine
    New York University School of Medicine
    Harvard Stem Cell Institute, Center for Brain Science, Broad Institute, Harvard University)

  • Brian Ciruna

    (Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine
    New York University School of Medicine
    University of Toronto
    The Program in Developmental and Stem Cell Biology, The Hospital for Sick Children)

  • William S. Talbot

    (Stanford University)

  • Alexander F. Schier

    (Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine
    New York University School of Medicine
    Harvard Stem Cell Institute, Center for Brain Science, Broad Institute, Harvard University)

Abstract

Arising from: A. V. Gore et al. Nature 438, 1030–1035 (2005)10.1038/nature04184 ; Gore et al. reply In fish and amphibians, the dorsal axis is specified by the asymmetric localization of maternally provided components of the Wnt signalling pathway1,2. Gore et al.3 suggest that the Nodal signal Squint (Sqt) is required as a maternally provided dorsal determinant in zebrafish. Here we test their proposal and show that the maternal activities of sqt and the related Nodal gene cyclops (cyc) are not required for dorsoventral patterning.

Suggested Citation

  • James T. Bennett & Heather L. Stickney & Wen-Yee Choi & Brian Ciruna & William S. Talbot & Alexander F. Schier, 2007. "Maternal nodal and zebrafish embryogenesis," Nature, Nature, vol. 450(7167), pages 1-2, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7167:d:10.1038_nature06314
    DOI: 10.1038/nature06314
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