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JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes

Author

Listed:
  • David Frescas

    (NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA)

  • Daniele Guardavaccaro

    (NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA)

  • Florian Bassermann

    (NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA)

  • Ryo Koyama-Nasu

    (NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA)

  • Michele Pagano

    (NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA)

Abstract

Gene repressors Histone modifications such as lysine methylation affect chromatin structure and gene expression. Histone methylation can be reversed by the JmjC-domain family of histone demethylases. One such histone demethylase, JHDM1B, has been suggested to be a tumour suppressor. In this issue Frescas et al. confirm a probable role for JHDM1B in cancer development. JHDM1B is shown to repress expression of ribosomal RNA genes, via the demethylation of the trimethylated lysine 4 residue of histone H3. JHDM1B also influences cell growth and proliferation, suggesting that reduced levels of JHDM1B promote tumour development.

Suggested Citation

  • David Frescas & Daniele Guardavaccaro & Florian Bassermann & Ryo Koyama-Nasu & Michele Pagano, 2007. "JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes," Nature, Nature, vol. 450(7167), pages 309-313, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7167:d:10.1038_nature06255
    DOI: 10.1038/nature06255
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