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Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

Author

Listed:
  • Di Yu

    (John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia)

  • Andy Hee-Meng Tan

    (Laboratory of Molecular and Cellular Immunology, Biomedical Sciences Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore)

  • Xin Hu

    (John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia)

  • Vicki Athanasopoulos

    (John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia
    ARC Centre for the Molecular Genetics of Development, Australian National University, Canberra, 2601, Australia)

  • Nicholas Simpson

    (John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia)

  • Diego G. Silva

    (John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia)

  • Andreas Hutloff

    (Molecular Immunology, Robert Koch-Institute, 13353, Berlin, Germany)

  • Keith M. Giles

    (Laboratory for Cancer Medicine, The University of Western Australia Centre for Medical Research, Western Australian Institute for Medical Research, Perth, 6000, Australia)

  • Peter J. Leedman

    (Laboratory for Cancer Medicine, The University of Western Australia Centre for Medical Research, Western Australian Institute for Medical Research, Perth, 6000, Australia
    School of Medicine and Pharmacology, The University of Western Australia, Perth, 6000, Australia)

  • Kong Peng Lam

    (Laboratory of Molecular and Cellular Immunology, Biomedical Sciences Institute, Agency for Science, Technology and Research (A*STAR), Singapore 138673, Singapore)

  • Christopher C. Goodnow

    (John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia
    Australian Phenomics Facility, Canberra, 2601, Australia)

  • Carola G. Vinuesa

    (John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia)

Abstract

The ubiquitin ligase Roquin suppresses inducible co-stimulator Icos expression on T cells thereby protecting mice from autoimmune disease. This paper shows that it does so through regulation of Icos messenger RNA stability.

Suggested Citation

  • Di Yu & Andy Hee-Meng Tan & Xin Hu & Vicki Athanasopoulos & Nicholas Simpson & Diego G. Silva & Andreas Hutloff & Keith M. Giles & Peter J. Leedman & Kong Peng Lam & Christopher C. Goodnow & Carola G., 2007. "Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA," Nature, Nature, vol. 450(7167), pages 299-303, November.
    • Handle: RePEc:nat:nature:v:450:y:2007:i:7167:d:10.1038_nature06253
    DOI: 10.1038/nature06253
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