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Regulation of cell cycle progression and gene expression by H2A deubiquitination

Author

Listed:
  • Heui-Yun Joo

    (University of Alabama at Birmingham, Kaul Human Genetics Building 402A, 720 South 20th Street, Birmingham, Alabama 35294, USA)

  • Ling Zhai

    (University of Alabama at Birmingham, Kaul Human Genetics Building 402A, 720 South 20th Street, Birmingham, Alabama 35294, USA)

  • Chunying Yang

    (University of Alabama at Birmingham, Kaul Human Genetics Building 402A, 720 South 20th Street, Birmingham, Alabama 35294, USA)

  • Shuyi Nie

    (University of Alabama at Birmingham, MCLM 360, Birmingham, Alabama 35294-0005, USA)

  • Hediye Erdjument-Bromage

    (Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA)

  • Paul Tempst

    (Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA)

  • Chenbei Chang

    (University of Alabama at Birmingham, MCLM 360, Birmingham, Alabama 35294-0005, USA)

  • Hengbin Wang

    (University of Alabama at Birmingham, Kaul Human Genetics Building 402A, 720 South 20th Street, Birmingham, Alabama 35294, USA)

Abstract

An enzyme, Ubp-M, is identified that removes the ubiquitin modification from histone H2A. Depletion of Ubp-M leads to slower cell growth and abnormal chromosome segregation in mitosis. In addition, depletion of Ubp-M causes defects in development and dysregulation of Hox gene expression.

Suggested Citation

  • Heui-Yun Joo & Ling Zhai & Chunying Yang & Shuyi Nie & Hediye Erdjument-Bromage & Paul Tempst & Chenbei Chang & Hengbin Wang, 2007. "Regulation of cell cycle progression and gene expression by H2A deubiquitination," Nature, Nature, vol. 449(7165), pages 1068-1072, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7165:d:10.1038_nature06256
    DOI: 10.1038/nature06256
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