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An elaborate pathway required for Ras-mediated epigenetic silencing

Author

Listed:
  • Claude Gazin

    (Howard Hughes Medical Institute and Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA)

  • Narendra Wajapeyee

    (Howard Hughes Medical Institute and Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA)

  • Stephane Gobeil

    (Howard Hughes Medical Institute and Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA)

  • Ching-Man Virbasius

    (Howard Hughes Medical Institute and Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA)

  • Michael R. Green

    (Howard Hughes Medical Institute and Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA)

Abstract

A genome-wide RNAi screen identifies several genes required for Ras-mediated epigenetic silencing that encode cell signalling molecules, chromatin modifiers, transcriptional activators and repressors, and the DNA methyltransferase DNMT1.

Suggested Citation

  • Claude Gazin & Narendra Wajapeyee & Stephane Gobeil & Ching-Man Virbasius & Michael R. Green, 2007. "An elaborate pathway required for Ras-mediated epigenetic silencing," Nature, Nature, vol. 449(7165), pages 1073-1077, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7165:d:10.1038_nature06251
    DOI: 10.1038/nature06251
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