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Functional architecture of the retromer cargo-recognition complex

Author

Listed:
  • Aitor Hierro

    (Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases,)

  • Adriana L. Rojas

    (Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases,)

  • Raul Rojas

    (Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, and,)

  • Namita Murthy

    (Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, and,)

  • Grégory Effantin

    (Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Andrey V. Kajava

    (Centre de Recherches de Biochimie Macromoléculaire, CNRS, University of Montpellier, 1919 Route de Mende, 34293 Montpellier, France)

  • Alasdair C. Steven

    (Laboratory of Structural Biology, National Institute of Arthritis, Musculoskeletal, and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Juan S. Bonifacino

    (Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, and,)

  • James H. Hurley

    (Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases,)

Abstract

The retromer is a complex of Vacuolar protein sorting proteins that mediate retrieval of lysosomal hydrolases from endosomes to the trans golgi network. The human retromer complex can be separated into two smaller complexes, a membrane targeting sorting nexin dimer and a heterotrimeric cargo recognition complex. New and previously solved structures, bioinformatics, interaction studies, molecular modelling and electron microscopy of the entire complex are combined to develop a structural model of the complex.

Suggested Citation

  • Aitor Hierro & Adriana L. Rojas & Raul Rojas & Namita Murthy & Grégory Effantin & Andrey V. Kajava & Alasdair C. Steven & Juan S. Bonifacino & James H. Hurley, 2007. "Functional architecture of the retromer cargo-recognition complex," Nature, Nature, vol. 449(7165), pages 1063-1067, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7165:d:10.1038_nature06216
    DOI: 10.1038/nature06216
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