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Clathrate nanostructures for mass spectrometry

Author

Listed:
  • Trent R. Northen

    (Department of Molecular Biology,
    Scripps Center for Mass Spectrometry,)

  • Oscar Yanes

    (Department of Molecular Biology,
    Scripps Center for Mass Spectrometry,)

  • Michael T. Northen

    (University of California at Santa Barbara, Santa Barbara, California 93106, USA)

  • Dena Marrinucci

    (The Scripps Research Institute, La Jolla, California 92037, USA)

  • Winnie Uritboonthai

    (Department of Molecular Biology,
    Scripps Center for Mass Spectrometry,)

  • Junefredo Apon

    (Department of Molecular Biology,
    Scripps Center for Mass Spectrometry,)

  • Stephen L. Golledge

    (CAMCOR Surface Analysis Facility at the University of Oregon, Eugene, Oregon 97403, USA)

  • Anders Nordström

    (Department of Molecular Biology,
    Scripps Center for Mass Spectrometry,)

  • Gary Siuzdak

    (Department of Molecular Biology,
    Scripps Center for Mass Spectrometry,)

Abstract

Explosive spectrometry Mass spectrometry has great potential for detecting biomolecules, but existing methods have several drawbacks, including a lack of sensitivity and the need for a matrix of molecules to promote analyte ionization. A dramatic new technique, using laser or ion beams to vaporize materials from nano-scale capsules, could overcome these limitations. It involves a specially prepared surface containing 'initiator' molecules that erupt violently when irradiated. This explosion releases ionized analyte molecules that were adsorbed to the surface, freeing them for detection. The method, dubbed NIMS (for nanostructure-initiator mass spectrometry), can analyse very small areas with extremely high sensitivity, allowing analysis of peptide microarrays, blood, urine and single cells, and it can even be used for tissue imaging.

Suggested Citation

  • Trent R. Northen & Oscar Yanes & Michael T. Northen & Dena Marrinucci & Winnie Uritboonthai & Junefredo Apon & Stephen L. Golledge & Anders Nordström & Gary Siuzdak, 2007. "Clathrate nanostructures for mass spectrometry," Nature, Nature, vol. 449(7165), pages 1033-1036, October.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7165:d:10.1038_nature06195
    DOI: 10.1038/nature06195
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    Cited by:

    1. Jiawei Xu & Tatsuya Fujino, 2018. "Vibrational Cooling Effect of Zeolite on Molecular Desorption Studied by Time-Resolved Laser Desorption Ionization Mass Spectrometry," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 12(1), pages 8943-8947, December.

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