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Structural basis for AMP binding to mammalian AMP-activated protein kinase

Author

Listed:
  • Bing Xiao

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Richard Heath

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Imperial College, DuCane Road, London W12 0NN, UK)

  • Peter Saiu

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Fiona C. Leiper

    (MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Imperial College, DuCane Road, London W12 0NN, UK)

  • Philippe Leone

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Chun Jing

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Philip A. Walker

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Lesley Haire

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • John F. Eccleston

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Colin T. Davis

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Stephen R. Martin

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • David Carling

    (MRC Clinical Sciences Centre, Hammersmith Hospital Campus, Imperial College, DuCane Road, London W12 0NN, UK)

  • Steven J. Gamblin

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

Abstract

AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis in mammals. This crystal structure of the trimeric regulatory fragment of mammalian AMPK reveals the modes of AMP and ATP binding.

Suggested Citation

  • Bing Xiao & Richard Heath & Peter Saiu & Fiona C. Leiper & Philippe Leone & Chun Jing & Philip A. Walker & Lesley Haire & John F. Eccleston & Colin T. Davis & Stephen R. Martin & David Carling & Steve, 2007. "Structural basis for AMP binding to mammalian AMP-activated protein kinase," Nature, Nature, vol. 449(7161), pages 496-500, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7161:d:10.1038_nature06161
    DOI: 10.1038/nature06161
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