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Transient activation of calcineurin is essential to initiate embryonic development in Xenopus laevis

Author

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  • Tomoko Nishiyama

    (Laboratory of Cell and Developmental Biology, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan)

  • Norio Yoshizaki

    (United Graduate School of Agricultural Science, Gifu University)

  • Takeo Kishimoto

    (Laboratory of Cell and Developmental Biology, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan)

  • Keita Ohsumi

    (Laboratory of Cell and Developmental Biology, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan)

Abstract

Calcineurin in fertilization The pathway from fertilization to an increase in the cytosolic Ca2+ concentration in eggs, a pivotal event in egg activation in multicellular organisms, has been clearly established but its downstream pathways are less explored. Two groups now report on this. They identify a new pathway involving the phosphatase, calcineurin. Calcium-induced activation of calcineurin is essential for the initiation of embryonic development in Xenopus, prompting the release of oocytes from a period of cell-cycle arrest in the M phase of meiosis following fertilization. A second wave of phosphatase activity then acts as a gateway to mitosis.

Suggested Citation

  • Tomoko Nishiyama & Norio Yoshizaki & Takeo Kishimoto & Keita Ohsumi, 2007. "Transient activation of calcineurin is essential to initiate embryonic development in Xenopus laevis," Nature, Nature, vol. 449(7160), pages 341-345, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7160:d:10.1038_nature06136
    DOI: 10.1038/nature06136
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