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Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2

Author

Listed:
  • Renaud Dentin

    (Peptide Biology Laboratories, Salk Institute For Biological Studies, La Jolla, California 92037, USA)

  • Yi Liu

    (Peptide Biology Laboratories, Salk Institute For Biological Studies, La Jolla, California 92037, USA)

  • Seung-Hoi Koo

    (Sungkyunkwan University School of Medicine, 300 Chunchun-dong, Jangan-gu, Suwon, 440-746, Gyeonggi-do, Korea)

  • Susan Hedrick

    (Peptide Biology Laboratories, Salk Institute For Biological Studies, La Jolla, California 92037, USA)

  • Thomas Vargas

    (Peptide Biology Laboratories, Salk Institute For Biological Studies, La Jolla, California 92037, USA)

  • Jose Heredia

    (Peptide Biology Laboratories, Salk Institute For Biological Studies, La Jolla, California 92037, USA)

  • John Yates

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Marc Montminy

    (Peptide Biology Laboratories, Salk Institute For Biological Studies, La Jolla, California 92037, USA)

Abstract

TORC2 and diabetes A previously unrecognized pathway by which insulin modulates hepatic glucose production is described in this issue. Glucose levels are maintained within a narrow range in mammals through the effects of pancreatic hormones on liver gluconeogenesis. This new pathway facilitates the inhibition of the expression of gluconeogenic genes by insulin by promoting the phosphorylation and ubiquitin-dependent degradation of the CREB coactivator TORC2. The signalling pathway involves the kinase SIK2 and the E3 ligase COP1. The findings point to TORC2 and SIK2 as potential therapeutic targets in type II diabetes.

Suggested Citation

  • Renaud Dentin & Yi Liu & Seung-Hoi Koo & Susan Hedrick & Thomas Vargas & Jose Heredia & John Yates & Marc Montminy, 2007. "Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2," Nature, Nature, vol. 449(7160), pages 366-369, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7160:d:10.1038_nature06128
    DOI: 10.1038/nature06128
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