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Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice

Author

Listed:
  • Mark A. Travis

    (Lung Biology Center, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA
    Present address: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, A3051 Smith Building, Oxford Road, Manchester M13 9PT, UK.)

  • Boris Reizis

    (Columbia University, 701 West 168th Street, Room 609, New York, New York 10032, USA)

  • Andrew C. Melton

    (Lung Biology Center, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA)

  • Emma Masteller

    (Diabetes Center, 513 Parnassus Avenue, University of San Francisco, San Francisco, California 94143, USA)

  • Qizhi Tang

    (Diabetes Center, 513 Parnassus Avenue, University of San Francisco, San Francisco, California 94143, USA)

  • John M. Proctor

    (Howard Hughes Medical Institute, University of California, San Francisco, California 94158, USA)

  • Yanli Wang

    (Lung Biology Center, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA)

  • Xin Bernstein

    (Lung Biology Center, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA)

  • Xiaozhu Huang

    (Lung Biology Center, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA)

  • Louis F. Reichardt

    (Howard Hughes Medical Institute, University of California, San Francisco, California 94158, USA)

  • Jeffrey A. Bluestone

    (Diabetes Center, 513 Parnassus Avenue, University of San Francisco, San Francisco, California 94143, USA)

  • Dean Sheppard

    (Lung Biology Center, University of California San Francisco, 1550 4th Street, Room 545, San Francisco, California 94158, USA)

Abstract

Balancing the immune forces Maintaining a balance between beneficial activation of immune responses and inappropriate immune attack of normal tissues requires multiple checks and balances. The cytokine TGF-β (transforming growth factor-β) is major player in one such pathway, as a negative regulator of adaptive immunity, but it has been unclear what activates TGF-β and which immune cells are critical to its action. Now the integrin αvβ8 has been identified as a critical activator of TGF-β; loss of this integrin on tissue dendritic cells activates TGF-β, which in turn induces regulatory T cells. In the absence of this pathway, mice develop autoimmunity and severe inflammation of the colon that resembles human ulcerative colitis.

Suggested Citation

  • Mark A. Travis & Boris Reizis & Andrew C. Melton & Emma Masteller & Qizhi Tang & John M. Proctor & Yanli Wang & Xin Bernstein & Xiaozhu Huang & Louis F. Reichardt & Jeffrey A. Bluestone & Dean Sheppar, 2007. "Loss of integrin αvβ8 on dendritic cells causes autoimmunity and colitis in mice," Nature, Nature, vol. 449(7160), pages 361-365, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7160:d:10.1038_nature06110
    DOI: 10.1038/nature06110
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