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Differential Notch signalling distinguishes neural stem cells from intermediate progenitors

Author

Listed:
  • Ken-ichi Mizutani

    (Institute for Cell Engineering,
    Department of Neurology,)

  • Keejung Yoon

    (Institute for Cell Engineering,
    Department of Neurology,
    Present address: Division of Brain Diseases, Center for Biomedical Sciences, National Institute of Health, Tongil-Lo 194, Eunpyung-Gu, Seoul, 122-701, Korea.)

  • Louis Dang

    (Institute for Cell Engineering,
    and)

  • Akinori Tokunaga

    (Institute for Cell Engineering,
    Department of Neurology,)

  • Nicholas Gaiano

    (Institute for Cell Engineering,
    Department of Neurology,
    and
    Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

Abstract

Stem cells go up a Notch The existence of different proliferative cell types in most stem cell systems is widely accepted, but the differences between these stem cells and restricted progenitor subsets are poorly understood. Now a team working at Johns Hopkins has discovered how two distinct cell populations in the developing mouse brain — 'true' neural stem cells and similar but less potent progenitors — are distinguished. The stem cells undergo stepwise maturation, gradually shedding 'stem cell' properties. The first step turns stem cells into 'progenitors' by dictating how signals downstream of Notch, a protein that regulates stem cells in many tissues, are transmitted. Then the two cell types diverge and the key factor here is whether a Notch signalling protein called CBF1 is active or not. CBF1 signalling plays the same role in blood stem cells, so it may be be a general 'switch' distinguishing stem cells from progenitors.

Suggested Citation

  • Ken-ichi Mizutani & Keejung Yoon & Louis Dang & Akinori Tokunaga & Nicholas Gaiano, 2007. "Differential Notch signalling distinguishes neural stem cells from intermediate progenitors," Nature, Nature, vol. 449(7160), pages 351-355, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7160:d:10.1038_nature06090
    DOI: 10.1038/nature06090
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