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Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon

Author

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  • Hongyan Wang

    (National University of Singapore)

  • Yingshi Ouyang

    (Stanford University School of Medicine, Geriatric Research, Education and Clinical Center (GRECC)/VA Palo Alto Health Care System (VAPAHCS), Palo Alto, California 94304, USA)

  • W. Gregory Somers

    (National University of Singapore)

  • William Chia

    (National University of Singapore)

  • Bingwei Lu

    (Stanford University School of Medicine, Geriatric Research, Education and Clinical Center (GRECC)/VA Palo Alto Health Care System (VAPAHCS), Palo Alto, California 94304, USA)

Abstract

A delicate balance A balance between self-renewal and differentiation is fundamental to stem cell and cancer biology. Drosophila neural stem cells achieve this through asymmetric cell division, during which factors influencing self-renewal and differentiation are unequally segregated. Wang et al. now show that the mitotic kinase Polo regulates the asymmetric localization of the tumour-suppressor protein Numb by phosphorylating Pon, the adaptor protein for Numb. Polo acts as a tumour suppressor by regulating Pon/Numb. These findings demonstrate a direct biochemical link between the cell cycle and asymmetric protein localization, and reveal a novel tumour suppressor mechanism.

Suggested Citation

  • Hongyan Wang & Yingshi Ouyang & W. Gregory Somers & William Chia & Bingwei Lu, 2007. "Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon," Nature, Nature, vol. 449(7158), pages 96-100, September.
    • Handle: RePEc:nat:nature:v:449:y:2007:i:7158:d:10.1038_nature06056
    DOI: 10.1038/nature06056
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