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A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

Author

Listed:
  • Kelly A. Frazer

    (Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA)

  • Eleazar Eskin

    (University of California, Los Angeles, Los Angeles, California 90095, USA)

  • Hyun Min Kang

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Molly A. Bogue

    (The Jackson Laboratory, Bar Harbor, Maine 04609, USA)

  • David A. Hinds

    (Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA)

  • Erica J. Beilharz

    (Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA)

  • Robert V. Gupta

    (Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA)

  • Julie Montgomery

    (Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA)

  • Matt M. Morenzoni

    (Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA)

  • Geoffrey B. Nilsen

    (Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA)

  • Charit L. Pethiyagoda

    (Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA)

  • Laura L. Stuve

    (Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA)

  • Frank M. Johnson

    (Toxicology Operations Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA)

  • Mark J. Daly

    (Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Center for Human Genetic Research, Massachussets General Hospital, 185 Cambridge St, Boston, Massachusetts 02114, USA)

  • Claire M. Wade

    (Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Center for Human Genetic Research, Massachussets General Hospital, 185 Cambridge St, Boston, Massachusetts 02114, USA)

  • David R. Cox

    (Perlegen Sciences, 2021 Stierlin Court, Mountain View, California 94043, USA)

Abstract

Putting mice on the HapMap A major new resource is now available to geneticists working on the many mouse models that are used to study toxicity and human disease. The genomes of four wild-derived and eleven inbred laboratory mouse strains have been resequenced to create a comprehensive resource of DNA variation. About 8.3 million single base-pair differences known as single nucleotide polymorphisms (SNPs) were identified. The data are publicly available as a mouse 'HapMap' at http://mouse.perlegen.com/ . The density and quality of this set of SNP markers is unprecedented for a mammalian genome, and it will provide a powerful tool for identifying the genetic determinants of phenotypic variation in the mouse.

Suggested Citation

  • Kelly A. Frazer & Eleazar Eskin & Hyun Min Kang & Molly A. Bogue & David A. Hinds & Erica J. Beilharz & Robert V. Gupta & Julie Montgomery & Matt M. Morenzoni & Geoffrey B. Nilsen & Charit L. Pethiyag, 2007. "A sequence-based variation map of 8.27 million SNPs in inbred mouse strains," Nature, Nature, vol. 448(7157), pages 1050-1053, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7157:d:10.1038_nature06067
    DOI: 10.1038/nature06067
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