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Small self-RNA generated by RNase L amplifies antiviral innate immunity

Author

Listed:
  • Krishnamurthy Malathi

    (Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA)

  • Beihua Dong

    (Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA)

  • Michael Gale

    (School of Medicine University of Washington, 1959 NE Pacific Street, H-578 Health Sciences, Box 357650 Seattle, Washington 98195-7650, USA)

  • Robert H. Silverman

    (Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA)

Abstract

Self confidence RNA molecules in virus-infected cells trigger interferon production and initiate antiviral innate immunity. Small RNA cleavage products from 'self' RNA generated by the antiviral endoribonuclease RNase L have now been found to initiate and amplify antiviral responses. This points to RNase L activation as a possible strategy for antiviral therapy.

Suggested Citation

  • Krishnamurthy Malathi & Beihua Dong & Michael Gale & Robert H. Silverman, 2007. "Small self-RNA generated by RNase L amplifies antiviral innate immunity," Nature, Nature, vol. 448(7155), pages 816-819, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7155:d:10.1038_nature06042
    DOI: 10.1038/nature06042
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