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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Author

Listed:
  • Thomas Korn

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Estelle Bettelli

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Wenda Gao

    (Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Amit Awasthi

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA)

  • Anneli Jäger

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Terry B. Strom

    (Transplant Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Mohamed Oukka

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA)

  • Vijay K. Kuchroo

    (Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

TH17 cells are a recently defined subset of pro-inflammatory helper T cells that are induced by the cytokines IL-6 and transforming growth factor (TGF)-β. TH17 can also be induced by an alternative pathway in which TGF-β cooperates with IL-21.

Suggested Citation

  • Thomas Korn & Estelle Bettelli & Wenda Gao & Amit Awasthi & Anneli Jäger & Terry B. Strom & Mohamed Oukka & Vijay K. Kuchroo, 2007. "IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells," Nature, Nature, vol. 448(7152), pages 484-487, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7152:d:10.1038_nature05970
    DOI: 10.1038/nature05970
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