Author
Listed:
- Shalina S. Ousman
(Stanford University)
- Beren H. Tomooka
(Stanford University School of Medicine, Stanford, California 94305, USA
GRECC and,)
- Johannes M. van Noort
(TNO Quality of Life, 2301 CE Leiden, The Netherlands)
- Eric F. Wawrousek
(National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA)
- Kevin O’Conner
(Center for Neurologic Disease, Harvard Medical School, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)
- David A. Hafler
(Center for Neurologic Disease, Harvard Medical School, Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)
- Raymond A. Sobel
(Laboratory Service, Veterans Affairs Palo Alto Health Care System, Palo Alto, California 94304, USA)
- William H. Robinson
(Stanford University School of Medicine, Stanford, California 94305, USA
GRECC and,)
- Lawrence Steinman
(Stanford University)
Abstract
Pivotal to multiple sclerosis? The protein αB-crystallin, found primarily in the lens of the eye, could be the critical 'tipping point' in the spiral of inflammation and damage that occurs in multiple sclerosis. It was known to be a major immune target in multiple sclerosis patients. Now work in mice shows that the protein plays a protective role in a model of multiple sclerosis. When injected in mice it acts as an anti-inflammatory and neuroprotective factor and can also reverse paralysis.
Suggested Citation
Shalina S. Ousman & Beren H. Tomooka & Johannes M. van Noort & Eric F. Wawrousek & Kevin O’Conner & David A. Hafler & Raymond A. Sobel & William H. Robinson & Lawrence Steinman, 2007.
"Protective and therapeutic role for αB-crystallin in autoimmune demyelination,"
Nature, Nature, vol. 448(7152), pages 474-479, July.
Handle:
RePEc:nat:nature:v:448:y:2007:i:7152:d:10.1038_nature05935
DOI: 10.1038/nature05935
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