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Delayed ageing through damage protection by the Arf/p53 pathway

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  • Ander Matheu

    (Tumor Suppression Group,
    Present address: Division of Stem Cell and Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK (A.M.); Catholic University of Valencia, 94 Guillem de Castro Street, Valencia 46003, Spain (C.B.).)

  • Antonio Maraver

    (Tumor Suppression Group,)

  • Peter Klatt

    (Tumor Suppression Group,)

  • Ignacio Flores

    (Telomeres and Telomerase Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain)

  • Isabel Garcia-Cao

    (Tumor Suppression Group,)

  • Consuelo Borras

    (University of Valencia, Valencia 46010, Spain
    Present address: Division of Stem Cell and Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK (A.M.); Catholic University of Valencia, 94 Guillem de Castro Street, Valencia 46003, Spain (C.B.).)

  • Juana M. Flores

    (Complutense University of Madrid, Madrid 28040, Spain)

  • Jose Viña

    (University of Valencia, Valencia 46010, Spain)

  • Maria A. Blasco

    (Telomeres and Telomerase Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain)

  • Manuel Serrano

    (Tumor Suppression Group,)

Abstract

Ageing and cancer linked The tumour suppressor activities of p53 protein and its regulator, Arf, are based on their involvement in detecting and eliminating damaged cells. Like cancer, ageing is associated with the accumulation of cellular damage and starting from that premise, Matheu et al. show that mice with increased, but otherwise normally regulated, levels of p53 and Arf are not only resistant to cancers, but also have a longer lifespan than normal mice regardless of the effects of the cancer. Remarkably, biological and molecular markers of ageing indicate that these mice stay 'younger' longer. Boosting endogenous Arf/p53 activity appears to provide an anti-oxidant effect that both suppresses cancers and delays ageing.

Suggested Citation

  • Ander Matheu & Antonio Maraver & Peter Klatt & Ignacio Flores & Isabel Garcia-Cao & Consuelo Borras & Juana M. Flores & Jose Viña & Maria A. Blasco & Manuel Serrano, 2007. "Delayed ageing through damage protection by the Arf/p53 pathway," Nature, Nature, vol. 448(7151), pages 375-379, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7151:d:10.1038_nature05949
    DOI: 10.1038/nature05949
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