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The Rab8 GTPase regulates apical protein localization in intestinal cells

Author

Listed:
  • Takashi Sato

    (Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan)

  • Sotaro Mushiake

    (Osaka University Graduate School of Medicine, Osaka 565-0871, Japan)

  • Yukio Kato

    (Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan)

  • Ken Sato

    (Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan)

  • Miyuki Sato

    (Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan)

  • Naoki Takeda

    (Center for Animal Resources and Development (CARD), IRDA, Kumamoto University, Kumamoto 860-0811, Japan)

  • Keiichi Ozono

    (Osaka University Graduate School of Medicine, Osaka 565-0871, Japan)

  • Kazunori Miki

    (Itami Municipal Hospital, Hyogo 664-8540, Japan)

  • Yoshiyuki Kubo

    (Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan)

  • Akira Tsuji

    (Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan)

  • Reiko Harada

    (Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan)

  • Akihiro Harada

    (Laboratory of Molecular Traffic, Institute for Molecular and Cellular Regulation, Gunma University, Gunma 371-8512, Japan)

Abstract

Rab8 is a small GTP-binding protein thought to regulate basolateral transport in vitro. In this paper, Rab8 conditional knockout mice are used to show that Rab8 plays an important part in vivo in the maintenance of the apical surface of intestinal cells; the mice eventually starve owing to poor absorption of food.

Suggested Citation

  • Takashi Sato & Sotaro Mushiake & Yukio Kato & Ken Sato & Miyuki Sato & Naoki Takeda & Keiichi Ozono & Kazunori Miki & Yoshiyuki Kubo & Akira Tsuji & Reiko Harada & Akihiro Harada, 2007. "The Rab8 GTPase regulates apical protein localization in intestinal cells," Nature, Nature, vol. 448(7151), pages 366-369, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7151:d:10.1038_nature05929
    DOI: 10.1038/nature05929
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