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An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum

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  • Samuel J. Fountain

    (Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK)

  • Katie Parkinson

    (Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK)

  • Mark T. Young

    (Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK)

  • Lishuang Cao

    (Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK)

  • Christopher R. L. Thompson

    (Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK)

  • R. Alan North

    (Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK)

Abstract

Membrane ion channels of the P2X class, which are gated by extracellular ATP, have been thought to be an exclusivity of multicellular organisms. Now, a functional P2X receptor in the social amoeba Dictyostelium discoideum has been found. It helps D. discoideum to adapt its cell volume to conditions of salinity. This discovery suggests vastly expanded modes of action for this important class of membrane receptors.

Suggested Citation

  • Samuel J. Fountain & Katie Parkinson & Mark T. Young & Lishuang Cao & Christopher R. L. Thompson & R. Alan North, 2007. "An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum," Nature, Nature, vol. 448(7150), pages 200-203, July.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7150:d:10.1038_nature05926
    DOI: 10.1038/nature05926
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