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Chromatin dynamics and the preservation of genetic information

Author

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  • Jessica A. Downs

    (MRC Genome Damage and Stability Centre, University of Sussex)

  • Michel C. Nussenzweig

    (Howard Hughes Medical Institute, The Rockefeller University)

  • André Nussenzweig

    (Experimental Immunology Branch, National Cancer Institute, National Institutes of Health)

Abstract

The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin — the fibres into which DNA is packaged with a proteinaceous structural polymer — has an important role in initiating, propagating and terminating this cellular response to DNA damage.

Suggested Citation

  • Jessica A. Downs & Michel C. Nussenzweig & André Nussenzweig, 2007. "Chromatin dynamics and the preservation of genetic information," Nature, Nature, vol. 447(7147), pages 951-958, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7147:d:10.1038_nature05980
    DOI: 10.1038/nature05980
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