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The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks

Author

Listed:
  • Michael Kruhlak

    (Experimental Immunology, NCI)

  • Elizabeth E. Crouch

    (Genomic Integrity and Immunity, NIAMS)

  • Marika Orlov

    (Genomic Integrity and Immunity, NIAMS)

  • Carolina Montaño

    (Genomic Integrity and Immunity, NIAMS)

  • Stanislaw A. Gorski

    (Biology of Genomes, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • André Nussenzweig

    (Experimental Immunology, NCI)

  • Tom Misteli

    (Biology of Genomes, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Robert D. Phair

    (Integrative Bioinformatics, Los Altos, California 94024, USA)

  • Rafael Casellas

    (Genomic Integrity and Immunity, NIAMS)

Abstract

DNA damage leads to transient repression of ribosomal gene transcription by RNA polymerase I in a pathway mediated by ATM kinase activity and the DNA repair factors Nbs1 and MDC1

Suggested Citation

  • Michael Kruhlak & Elizabeth E. Crouch & Marika Orlov & Carolina Montaño & Stanislaw A. Gorski & André Nussenzweig & Tom Misteli & Robert D. Phair & Rafael Casellas, 2007. "The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks," Nature, Nature, vol. 447(7145), pages 730-734, June.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7145:d:10.1038_nature05842
    DOI: 10.1038/nature05842
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