IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v447y2007i7143d10.1038_nature05804.html
   My bibliography  Save this article

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

Author

Listed:
  • G. C. Fox

    (Structural Biology Laboratory and,
    Present address: ESRF, 6 Rue Jules Horowitz, 38043 Grenoble, Cedex 9, France.)

  • M. Shafiq

    (Structural Biology Laboratory and,)

  • D. C. Briggs

    (Structural Biology Laboratory and,)

  • P. P. Knowles

    (Structural Biology Laboratory and,)

  • M. Collister

    (Cancer Research UK, Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, UK)

  • M. J. Didmon

    (Cancer Research UK, Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, UK)

  • V. Makrantoni

    (College of Life Sciences, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH, UK)

  • R. J. Dickinson

    (Cancer Research UK, Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, UK)

  • S. Hanrahan

    (Protein Analysis Laboratory, The London Research Institute, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK)

  • N. Totty

    (Protein Analysis Laboratory, The London Research Institute, Cancer Research UK, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK)

  • M. J. R. Stark

    (College of Life Sciences, MSI/WTB Complex, University of Dundee, Dundee DD1 5EH, UK)

  • S. M. Keyse

    (Cancer Research UK, Stress Response Laboratory, Biomedical Research Centre, Ninewells Hospital, Dundee DD1 9SY, UK)

  • N. Q. McDonald

    (Structural Biology Laboratory and,
    School of Crystallography, Birkbeck College, Malet Street, London WC1E 7HX, UK)

Abstract

The stress-induced yeast MAPK phosphatase Sdp1 acquires enhanced activity under oxidative conditions by forming an intramolecular disulphide bond that is used to recognize a tyrosine-phosphorylated substrate.

Suggested Citation

  • G. C. Fox & M. Shafiq & D. C. Briggs & P. P. Knowles & M. Collister & M. J. Didmon & V. Makrantoni & R. J. Dickinson & S. Hanrahan & N. Totty & M. J. R. Stark & S. M. Keyse & N. Q. McDonald, 2007. "Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases," Nature, Nature, vol. 447(7143), pages 487-492, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7143:d:10.1038_nature05804
    DOI: 10.1038/nature05804
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05804
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05804?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:447:y:2007:i:7143:d:10.1038_nature05804. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.