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Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity

Author

Listed:
  • Iraj Saadat

    (Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan)

  • Hideaki Higashi

    (Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan)

  • Chikashi Obuse

    (Hokkaido University, Graduate School of Life Science, Sapporo 001-0021, Japan)

  • Mayumi Umeda

    (Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan)

  • Naoko Murata-Kamiya

    (Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan)

  • Yasuhiro Saito

    (Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan)

  • Huaisheng Lu

    (Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan)

  • Naomi Ohnishi

    (Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan)

  • Takeshi Azuma

    (Internal Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan)

  • Atsushi Suzuki

    (Yokohama City University Graduate School of Medical Science, Yokohama 236-0004, Japan)

  • Shigeo Ohno

    (Yokohama City University Graduate School of Medical Science, Yokohama 236-0004, Japan)

  • Masanori Hatakeyama

    (Graduate School of Science, Hokkaido University, Sapporo 060-0815, Japan)

Abstract

H. pylori beats PAR Helicobacter pylori infects more than half of the world's population, and though usually well tolerated, it can cause gastric mucosal damage, peptic ulcers, gastritis and adenocarcinoma. CagA is the main virulence factor of H. pylori, delivered directly by the bacterium into epithelial cells where it interferes with cell signalling. CagA is now shown to bind to the polarity protein, Par-1, inhibiting its phosphorylation and disrupting epithelial cell polarity. This study provides the first molecular link between a human pathogen and the PAR cell polarity machinery, and points to a possible general role for PAR1 inhibition in gastrointestinal carcinogenesis.

Suggested Citation

  • Iraj Saadat & Hideaki Higashi & Chikashi Obuse & Mayumi Umeda & Naoko Murata-Kamiya & Yasuhiro Saito & Huaisheng Lu & Naomi Ohnishi & Takeshi Azuma & Atsushi Suzuki & Shigeo Ohno & Masanori Hatakeyama, 2007. "Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity," Nature, Nature, vol. 447(7142), pages 330-333, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7142:d:10.1038_nature05765
    DOI: 10.1038/nature05765
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    Cited by:

    1. Ji Yeong Yang & Pumsoo Kim & Seok-Hoo Jeong & Seong Woong Lee & Yu Sik Myung & Myong Ki Baeg & Jong-Bae Kim, 2020. "The Effects of Sulglycotide on the Adhesion and the Inflammation of Helicobacter Pylori," IJERPH, MDPI, vol. 17(8), pages 1-9, April.

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