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The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Author

Listed:
  • Travis H. Stracker

    (Molecular Biology and Genetics, Sloan-Kettering Institute, and)

  • Monica Morales

    (Molecular Biology and Genetics, Sloan-Kettering Institute, and)

  • Suzana S. Couto

    (Pathology and Laboratory Medicine, Memorial Sloan-Kettering Cancer Center, and)

  • Hussein Hussein

    (Molecular Biology and Genetics, Sloan-Kettering Institute, and)

  • John H. J. Petrini

    (Molecular Biology and Genetics, Sloan-Kettering Institute, and
    Weill-Cornell Graduate School of Medical Science, New York, New York 10021, USA)

Abstract

Although the C-terminal domain of the protein Nbs1 is required for interaction with ATM, it is unexpectedly not required for most downstream ATM-dependent damage repair events. Instead, the most notable effect seen when this interaction domain is absent is loss of the ability of ATM to induce apoptosis.

Suggested Citation

  • Travis H. Stracker & Monica Morales & Suzana S. Couto & Hussein Hussein & John H. J. Petrini, 2007. "The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex," Nature, Nature, vol. 447(7141), pages 218-221, May.
    • Handle: RePEc:nat:nature:v:447:y:2007:i:7141:d:10.1038_nature05740
    DOI: 10.1038/nature05740
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    Cited by:

    1. Soonjoung Kim & Shintaro Yamada & Tao Li & Claudia Canasto-Chibuque & Jun Hyun Kim & Marina Marcet-Ortega & Jiaqi Xu & Diana Y. Eng & Laura Feeney & John H. J. Petrini & Scott Keeney, 2025. "Mouse MRE11-RAD50-NBS1 is needed to start and extend meiotic DNA end resection," Nature Communications, Nature, vol. 16(1), pages 1-20, December.

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