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Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins

Author

Listed:
  • Gerald W. Hart

    (Johns Hopkins University, School of Medicine)

  • Michael P. Housley

    (Johns Hopkins University, School of Medicine)

  • Chad Slawson

    (Johns Hopkins University, School of Medicine)

Abstract

All animals and plants dynamically attach and remove O-linked β-N-acetylglucosamine (O-GlcNAc) at serine and threonine residues on myriad nuclear and cytoplasmic proteins. O-GlcNAc cycling, which is tightly regulated by the concerted actions of two highly conserved enzymes, serves as a nutrient and stress sensor. On some proteins, O-GlcNAc competes directly with phosphate for serine/threonine residues. Glycosylation with O-GlcNAc modulates signalling, and influences protein expression, degradation and trafficking. Emerging data indicate that O-GlcNAc glycosylation has a role in the aetiology of diabetes and neurodegeneration.

Suggested Citation

  • Gerald W. Hart & Michael P. Housley & Chad Slawson, 2007. "Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins," Nature, Nature, vol. 446(7139), pages 1017-1022, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7139:d:10.1038_nature05815
    DOI: 10.1038/nature05815
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    Cited by:

    1. Gordan Lauc & Abdelkader Essafi & Jennifer E Huffman & Caroline Hayward & Ana Knežević & Jayesh J Kattla & Ozren Polašek & Olga Gornik & Veronique Vitart & Jodie L Abrahams & Maja Pučić & Mislav Novok, 2010. "Genomics Meets Glycomics—The First GWAS Study of Human N-Glycome Identifies HNF1α as a Master Regulator of Plasma Protein Fucosylation," PLOS Genetics, Public Library of Science, vol. 6(12), pages 1-14, December.
    2. Shahzina Kanwal & Yann Fardini & Patrick Pagesy & Thierry N’Tumba-Byn & Cécile Pierre-Eugène & Elodie Masson & Cornelia Hampe & Tarik Issad, 2013. "O-GlcNAcylation-Inducing Treatments Inhibit Estrogen Receptor α Expression and Confer Resistance to 4-OH-Tamoxifen in Human Breast Cancer-Derived MCF-7 Cells," PLOS ONE, Public Library of Science, vol. 8(7), pages 1-1, July.

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