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Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers

Author

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  • Ananda K. Sarkar

    (Institute of Biology III, University of Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany
    Present addresses: Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA (A.K.S.); John Innes Centre, Colney Lane, Norwich, N4 7UH, UK (M.K.).)

  • Marijn Luijten

    (Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands)

  • Shunsuke Miyashima

    (Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan)

  • Michael Lenhard

    (Institute of Biology III, University of Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany
    Present addresses: Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, New York 11724, USA (A.K.S.); John Innes Centre, Colney Lane, Norwich, N4 7UH, UK (M.K.).)

  • Takashi Hashimoto

    (Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan)

  • Keiji Nakajima

    (Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan)

  • Ben Scheres

    (Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands)

  • Renze Heidstra

    (Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands)

  • Thomas Laux

    (Institute of Biology III, University of Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany)

Abstract

Root and branch stem cells Plants have two apparently distinct stem cell niches, in the root and stem meristems, dividing perpetually to produce new tissues and organs. Previous studies have highlighted the different modes of development and different control genes in the two systems, but Sarkar et al. now show that there is a strong mechanistic link between them. The signalling centres of both niches utilize related transcription factors, WUSCHEL in the shoot and WOX5 in the roots, to maintain neighbouring stem cells undifferentiated, and these two factors act in both meristems to maintain normal function. This finding provides molecular evidence that the stem cell regulatory system originated before root and shoots separated in land plants from which the current higher plants are derived.

Suggested Citation

  • Ananda K. Sarkar & Marijn Luijten & Shunsuke Miyashima & Michael Lenhard & Takashi Hashimoto & Keiji Nakajima & Ben Scheres & Renze Heidstra & Thomas Laux, 2007. "Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers," Nature, Nature, vol. 446(7137), pages 811-814, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7137:d:10.1038_nature05703
    DOI: 10.1038/nature05703
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