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Myc deletion rescues Apc deficiency in the small intestine

Author

Listed:
  • Owen J. Sansom

    (The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK)

  • Valerie S. Meniel

    (Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK)

  • Vanesa Muncan

    (Hubrecht Laboratory, Nederlands Institute for Developmental Biology, Upsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Toby J. Phesse

    (Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK)

  • Julie A. Wilkins

    (The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK)

  • Karen R. Reed

    (Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK)

  • J. Keith Vass

    (The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK)

  • Dimitris Athineos

    (The Beatson Institute, Garscube Estate, Glasgow G61 1BD, UK)

  • Hans Clevers

    (Hubrecht Laboratory, Nederlands Institute for Developmental Biology, Upsalalaan 8, 3584 CT Utrecht, The Netherlands)

  • Alan R. Clarke

    (Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, UK)

Abstract

Deregulation of the Wnt signalling pathway has been implicated in the development of cancer, including colorectal tumours. This paper shows that regulation of the transcription factor c-Myc is the most critical target for Wnt signalling in the early stages of intestinal neoplasias.

Suggested Citation

  • Owen J. Sansom & Valerie S. Meniel & Vanesa Muncan & Toby J. Phesse & Julie A. Wilkins & Karen R. Reed & J. Keith Vass & Dimitris Athineos & Hans Clevers & Alan R. Clarke, 2007. "Myc deletion rescues Apc deficiency in the small intestine," Nature, Nature, vol. 446(7136), pages 676-679, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7136:d:10.1038_nature05674
    DOI: 10.1038/nature05674
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