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Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Author

Listed:
  • Masahiro Ono

    (Institute for Frontier Medical Sciences, and
    Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan)

  • Hiroko Yaguchi

    (Tumor Endocrinology Project, and,)

  • Naganari Ohkura

    (Tumor Endocrinology Project, and,)

  • Issay Kitabayashi

    (National Cancer Center Research Institute, Chuo-ku, Tokyo, 104-0045, Japan)

  • Yuko Nagamura

    (Tumor Endocrinology Project, and,)

  • Takashi Nomura

    (Institute for Frontier Medical Sciences, and)

  • Yoshiki Miyachi

    (Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan)

  • Toshihiko Tsukada

    (Tumor Endocrinology Project, and,)

  • Shimon Sakaguchi

    (Institute for Frontier Medical Sciences, and
    Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Kawaguchi 332-0012, Japan)

Abstract

Immunity tamed CD25+CD4+ regulatory T cells or 'Tregs' are vital to the immune system, suppressing aberrant or excessive immune responses such as autoimmune disease and allergy. Ono et al. find that Tregs act via the interaction of the transcription factors AML1/Runx1 and Foxp3. This interaction is therefore a potential therapeutic target for controlling immune responses.

Suggested Citation

  • Masahiro Ono & Hiroko Yaguchi & Naganari Ohkura & Issay Kitabayashi & Yuko Nagamura & Takashi Nomura & Yoshiki Miyachi & Toshihiko Tsukada & Shimon Sakaguchi, 2007. "Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1," Nature, Nature, vol. 446(7136), pages 685-689, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7136:d:10.1038_nature05673
    DOI: 10.1038/nature05673
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