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Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin

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  • Jun-Li Luo

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Wei Tan

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Jill M. Ricono

    (University of California, San Diego, La Jolla, California 92093-0803, USA)

  • Olexandr Korchynskyi

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Ming Zhang

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Steven L. Gonias

    (University of California, San Diego, La Jolla, California 92093-0803, USA)

  • David A. Cheresh

    (University of California, San Diego, La Jolla, California 92093-0803, USA)

  • Michael Karin

    (Laboratory of Gene Regulation and Signal Transduction, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

Abstract

RANK key to metastasis Experiments in a mouse prostate cancer model have identified a signalling pathway that stimulates the formation of metastases. The pathway is initiated when a protein ligand occupies a receptor known as RANK (receptor activator of nuclear factor κB), and is dependent on the activation and nuclear translocation of IKKα (IκB kinase α). Once in the nucleus, activated IKKα represses maspin gene transcription, whose product is well established as an inhibitor of cell migration and invasion in prostate and breast cancer. RANK may therefore be a general promoter of metastatic behaviour in prostate or mammary carcinoma cells.

Suggested Citation

  • Jun-Li Luo & Wei Tan & Jill M. Ricono & Olexandr Korchynskyi & Ming Zhang & Steven L. Gonias & David A. Cheresh & Michael Karin, 2007. "Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin," Nature, Nature, vol. 446(7136), pages 690-694, April.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7136:d:10.1038_nature05656
    DOI: 10.1038/nature05656
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