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Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre

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  • Joanna Krzemień

    (Centre de Biologie du Développement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse cedex 09, France
    Jagiellonian University, The Institute of Zoology, 6 Ingardena Street, 30-060 Cracow, Poland)

  • Laurence Dubois

    (Centre de Biologie du Développement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse cedex 09, France)

  • Rami Makki

    (Centre de Biologie du Développement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse cedex 09, France)

  • Marie Meister

    (UPR 9022 du CNRS, IBMC, 15 rue René Descartes, 67084 Strasbourg, France
    Present address: Museum of Zoology, 29 boulevard de la Victoire, 67000 Strasbourg, France.)

  • Alain Vincent

    (Centre de Biologie du Développement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse cedex 09, France)

  • Michèle Crozatier

    (Centre de Biologie du Développement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse cedex 09, France)

Abstract

Signals in the blood This week, two papers from separate groups define a signalling centre in the Drosophila lymph gland that controls maintenance of blood cell precursors. Signals generated in the posterior signalling centre of the lymph gland control the balance of progenitors and differentiating blood cells through JAK/STAT and Notch signalling pathways. Mandal et al. also show that the signalling centre is specified early in embryonic development by the homeotic gene Antennapedia. And Krzemień et al. show that Notch signalling controls Collier, the Drosophila equivalent of mammalian early B cell factor. This work suggests that the Drosophila model for blood development could be an important tool for genetic manipulation.

Suggested Citation

  • Joanna Krzemień & Laurence Dubois & Rami Makki & Marie Meister & Alain Vincent & Michèle Crozatier, 2007. "Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre," Nature, Nature, vol. 446(7133), pages 325-328, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7133:d:10.1038_nature05650
    DOI: 10.1038/nature05650
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    Cited by:

    1. Bayan Kharrat & Erika Gábor & Nikolett Virág & Rita Sinka & Ferenc Jankovics & Ildikó Kristó & Péter Vilmos & Gábor Csordás & Viktor Honti, 2024. "Dual role for Headcase in hemocyte progenitor fate determination in Drosophila melanogaster," PLOS Genetics, Public Library of Science, vol. 20(10), pages 1-25, October.
    2. Xiaohui Liu & Marianne Montemurro & Nathalie Vanzo & Michèle Crozatier, 2025. "Serotonergic neurons regulate the Drosophila vascular niche to control immune stress hematopoiesis," Nature Communications, Nature, vol. 16(1), pages 1-16, December.

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