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The molecular choreography of a store-operated calcium channel

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  • Richard S. Lewis

    (Stanford University School of Medicine, Stanford, California 94305, USA)

Abstract

A good SOCE Store-operated Ca2+ entry (SOCE) is a signalling process whereby a decrease in the concentration of Ca2+ in the endoplasmic reticulum (ER) triggers Ca2+ influx via channels in the plasma membrane. SOCE has been detected in many types of excitable and non-excitable cells, involved in essential functions such as secretion and immunity. Despite intense interest in SOCE, its molecular basis remained elusive until recently, when genes for the ER Ca2+ sensor and Ca2+ release-activated Ca2+ (CRAC) channel were identified. A molecular picture of CRAC channel activation and SOCE is now starting to emerge.

Suggested Citation

  • Richard S. Lewis, 2007. "The molecular choreography of a store-operated calcium channel," Nature, Nature, vol. 446(7133), pages 284-287, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7133:d:10.1038_nature05637
    DOI: 10.1038/nature05637
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