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Erratum: The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production

Author

Listed:
  • L. Pastorino
  • A. Sun
  • P.-J. Lu
  • X. Z. Zhou
  • M. Balastik
  • G. Finn
  • G. Wulf
  • J. Lim
  • S.-H. Li
  • X. Li
  • W. Xia
  • L. K. Nicholson
  • K. P. Lu

Abstract

Nature 440, 528–534 (2006) During editing to meet Nature’s limits on length, we removed a reference to an earlier paper1 reporting that the prolyl isomerase Pin1 promotes production of Alzheimer’s amyloid-β (Aβ) from β-cleaved amyloid precursor protein (APP). That paper reported that Pin1 did not bind to full-length APP, but rather to the phosphorylated Thr 668–Pro motif of the carboxy-terminal C99 fragment of APP; Aβ production in Pin1-knockout mice was reduced only from this fragment.

Suggested Citation

  • L. Pastorino & A. Sun & P.-J. Lu & X. Z. Zhou & M. Balastik & G. Finn & G. Wulf & J. Lim & S.-H. Li & X. Li & W. Xia & L. K. Nicholson & K. P. Lu, 2007. "Erratum: The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-β production," Nature, Nature, vol. 446(7133), pages 342-342, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7133:d:10.1038_nature05606
    DOI: 10.1038/nature05606
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