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A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors

Author

Listed:
  • Lolitika Mandal

    (Cell and Developmental Biology, Molecular Biology Institute)

  • Julian A. Martinez-Agosto

    (Mattel Children’s Hospital at UCLA, University of California, Los Angeles, Los Angeles, California 90095, USA)

  • Cory J. Evans

    (Cell and Developmental Biology, Molecular Biology Institute)

  • Volker Hartenstein

    (Cell and Developmental Biology, Molecular Biology Institute)

  • Utpal Banerjee

    (Cell and Developmental Biology, Molecular Biology Institute
    Department of Biological Chemistry,)

Abstract

Signals in the blood This week, two papers from separate groups define a signalling centre in the Drosophila lymph gland that controls maintenance of blood cell precursors. Signals generated in the posterior signalling centre of the lymph gland control the balance of progenitors and differentiating blood cells through JAK/STAT and Notch signalling pathways. Mandal et al. also show that the signalling centre is specified early in embryonic development by the homeotic gene Antennapedia. And Krzemień et al. show that Notch signalling controls Collier, the Drosophila equivalent of mammalian early B cell factor. This work suggests that the Drosophila model for blood development could be an important tool for genetic manipulation.

Suggested Citation

  • Lolitika Mandal & Julian A. Martinez-Agosto & Cory J. Evans & Volker Hartenstein & Utpal Banerjee, 2007. "A Hedgehog- and Antennapedia-dependent niche maintains Drosophila haematopoietic precursors," Nature, Nature, vol. 446(7133), pages 320-324, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7133:d:10.1038_nature05585
    DOI: 10.1038/nature05585
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    Cited by:

    1. Xiaohui Liu & Marianne Montemurro & Nathalie Vanzo & Michèle Crozatier, 2025. "Serotonergic neurons regulate the Drosophila vascular niche to control immune stress hematopoiesis," Nature Communications, Nature, vol. 16(1), pages 1-16, December.

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