IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v446y2007i7133d10.1038_nature05542.html
   My bibliography  Save this article

A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate

Author

Listed:
  • Wei Li

    (Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Daqi Tu

    (The Howard Hughes Medical Institute, Neurology and Neurological Sciences, Structural Biology, and SSRL, Stanford University, Stanford, California 94305-5489, USA)

  • Axel T. Brunger

    (The Howard Hughes Medical Institute, Neurology and Neurological Sciences, Structural Biology, and SSRL, Stanford University, Stanford, California 94305-5489, USA)

  • Yihong Ye

    (Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA)

Abstract

It is demonstrated that polyubiquitination mediated by Ube2g2 (E2) and gp78 (E3) employs a mechanism that involves preassembly of Lys48-linked ubiquitin chains at the catalytic cysteine of Ube2g2. Polyubiquitination of a substrate can be achieved by transferring the preassembled ubiquitin chains from Ube2g2 to a lysine residue in a substrate.

Suggested Citation

  • Wei Li & Daqi Tu & Axel T. Brunger & Yihong Ye, 2007. "A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate," Nature, Nature, vol. 446(7133), pages 333-337, March.
    • Handle: RePEc:nat:nature:v:446:y:2007:i:7133:d:10.1038_nature05542
    DOI: 10.1038/nature05542
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature05542
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature05542?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to

    for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:446:y:2007:i:7133:d:10.1038_nature05542. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.